Pubertal development and prostate cancer risk: Mendelian randomization study in a population-based cohort
Identifieur interne : 001876 ( Main/Exploration ); précédent : 001875; suivant : 001877Pubertal development and prostate cancer risk: Mendelian randomization study in a population-based cohort
Auteurs : Carolina Bonilla [Royaume-Uni] ; Sarah J. Lewis [Royaume-Uni] ; Richard M. Martin [Royaume-Uni] ; Jenny L. Donovan [Royaume-Uni] ; Freddie C. Hamdy [Royaume-Uni] ; David E. Neal [Royaume-Uni] ; Rosalind Eeles [Royaume-Uni] ; Doug Easton [Royaume-Uni] ; Zsofia Kote-Jarai ; Ali Amin Al Olama [Royaume-Uni] ; Sara Benlloch [Royaume-Uni] ; Kenneth Muir [Royaume-Uni] ; Graham G. Giles [Australie] ; Fredrik Wiklund [Suède] ; Henrik Gronberg [Suède] ; Christopher A. Haiman [États-Unis] ; Johanna Schleutker [Finlande] ; B Rge G. Nordestgaard ; Ruth C. Travis [Royaume-Uni] ; Nora Pashayan [Royaume-Uni] ; Kay-Tee Khaw [Royaume-Uni] ; Janet L. Stanford [États-Unis] ; William J. Blot [États-Unis] ; Stephen Thibodeau [États-Unis] ; Christiane Maier [Allemagne] ; Adam S. Kibel [États-Unis] ; Cezary Cybulski [Pologne] ; Lisa Cannon-Albright [États-Unis] ; Hermann Brenner [Allemagne] ; Jong Park [États-Unis] ; Radka Kaneva [Bulgarie] ; Jyotsna Batra [Australie] ; Manuel R. Teixeira [Portugal] ; Hardev Pandha ; Mark Lathrop [France, Canada] ; George Davey Smith [Royaume-Uni]Source :
- BMC Medicine [ 1741-7015 ] ; 2016.
Descripteurs français
- KwdFr :
- Adolescent, Adulte d'âge moyen, Analyse de randomisation mendélienne (), Analyse de régression, Analyse de survie, Attribution aléatoire, Facteurs de risque, Humains, Maturation sexuelle (génétique), Mâle, Odds ratio, Polymorphisme de nucléotide simple, Puberté (physiologie), Royaume-Uni (épidémiologie), Stade de la tumeur, Sujet âgé, Tumeurs de la prostate (anatomopathologie), Tumeurs de la prostate (génétique), Tumeurs de la prostate (physiopathologie), Tumeurs de la prostate (épidémiologie), Âge de début, Étude d'association pangénomique, Études cas-témoins.
- MESH :
- anatomopathologie : Tumeurs de la prostate.
- génétique : Maturation sexuelle, Tumeurs de la prostate.
- physiologie : Puberté.
- physiopathologie : Tumeurs de la prostate.
- épidémiologie : Royaume-Uni, Tumeurs de la prostate.
- Adolescent, Adulte d'âge moyen, Analyse de randomisation mendélienne, Analyse de régression, Analyse de survie, Attribution aléatoire, Facteurs de risque, Humains, Mâle, Odds ratio, Polymorphisme de nucléotide simple, Stade de la tumeur, Sujet âgé, Âge de début, Étude d'association pangénomique, Études cas-témoins.
English descriptors
- KwdEn :
- Adolescent, Age of Onset, Aged, Case-Control Studies, Genome-Wide Association Study, Humans, Male, Mendelian Randomization Analysis (methods), Middle Aged, Neoplasm Staging, Odds Ratio, Polymorphism, Single Nucleotide, Prostatic Neoplasms (epidemiology), Prostatic Neoplasms (genetics), Prostatic Neoplasms (pathology), Prostatic Neoplasms (physiopathology), Puberty (physiology), Random Allocation, Regression Analysis, Risk Factors, Sexual Maturation (genetics), Survival Analysis, United Kingdom (epidemiology).
- MESH :
- epidemiology : Prostatic Neoplasms, United Kingdom.
- genetics : Prostatic Neoplasms, Sexual Maturation.
- methods : Mendelian Randomization Analysis.
- pathology : Prostatic Neoplasms.
- physiology : Puberty.
- physiopathology : Prostatic Neoplasms.
- Adolescent, Age of Onset, Aged, Case-Control Studies, Genome-Wide Association Study, Humans, Male, Middle Aged, Neoplasm Staging, Odds Ratio, Polymorphism, Single Nucleotide, Random Allocation, Regression Analysis, Risk Factors, Survival Analysis.
Abstract
Epidemiological studies have observed a positive association between an earlier age at sexual development and prostate cancer, but markers of sexual maturation in boys are imprecise and observational estimates are likely to suffer from a degree of uncontrolled confounding. To obtain causal estimates, we examined the role of pubertal development in prostate cancer using genetic polymorphisms associated with Tanner stage in adolescent boys in a Mendelian randomization (MR) approach.
We derived a weighted genetic risk score for pubertal development, combining 13 SNPs associated with male Tanner stage. A higher score indicated a later puberty onset. We examined the association of this score with prostate cancer risk, stage and grade in the UK-based ProtecT case-control study (
In ProtecT, the puberty genetic score was inversely associated with prostate cancer grade (odds ratio (OR) of high- vs. low-grade cancer, per tertile of the score: 0.76; 95 % CI, 0.64–0.89). In an instrumental variable estimation of the causal OR, later physical development in adolescence (equivalent to a difference of one Tanner stage between pubertal boys of the same age) was associated with a 77 % (95 % CI, 43–91 %) reduced odds of high Gleason prostate cancer. In PRACTICAL, the puberty genetic score was associated with prostate cancer stage (OR of advanced vs. localized cancer, per tertile: 0.95; 95 % CI, 0.91–1.00) and prostate cancer-specific mortality (hazard ratio amongst cases, per tertile: 0.94; 95 % CI, 0.90–0.98), but not with disease grade.
Older age at sexual maturation is causally linked to a reduced risk of later prostate cancer, especially aggressive disease.
The online version of this article (doi:10.1186/s12916-016-0602-x) contains supplementary material, which is available to authorized users.
Url:
DOI: 10.1186/s12916-016-0602-x
PubMed: 27044414
PubMed Central: 4820939
Affiliations:
- Allemagne, Australie, Bulgarie, Canada, Finlande, France, Pologne, Portugal, Royaume-Uni, Suède, États-Unis
- Angleterre, Angleterre de l'Est, Bade-Wurtemberg, Californie, District de Karlsruhe, District de Tübingen, Finlande occidentale, Floride, Grand Londres, Grand Manchester, Maryland, Massachusetts, Minnesota, Missouri (État), Oxfordshire, Québec, Sofia-ville (oblast), Svealand, Utah, Victoria (État), Washington (État), Île-de-France
- Cambridge, Heidelberg, Londres, Manchester, Melbourne, Montréal, Oxford, Sofia, Stockholm, Turku, Ulm, Évry (Essonne)
- University College de Londres, Université d'Oxford, Université de Cambridge, Université de Manchester, Université de Melbourne, Université de Turku
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000B03
- to stream Pmc, to step Curation: 000A80
- to stream Pmc, to step Checkpoint: 000671
- to stream PubMed, to step Corpus: 001F84
- to stream PubMed, to step Curation: 001F59
- to stream PubMed, to step Checkpoint: 001F59
- to stream Ncbi, to step Merge: 003362
- to stream Ncbi, to step Curation: 003362
- to stream Ncbi, to step Checkpoint: 003362
- to stream Main, to step Merge: 001871
- to stream Main, to step Curation: 001876
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Pubertal development and prostate cancer risk: Mendelian randomization study in a population-based cohort</title><author><name sortKey="Bonilla, Carolina" sort="Bonilla, Carolina" uniqKey="Bonilla C" first="Carolina" last="Bonilla">Carolina Bonilla</name><affiliation wicri:level="1"><nlm:aff id="Aff1">School of Social and Community Medicine, University of Bristol, Bristol, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>School of Social and Community Medicine, University of Bristol, Bristol</wicri:regionArea><wicri:noRegion>Bristol</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff2">MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Integrative Epidemiology Unit at the University of Bristol, Bristol</wicri:regionArea><wicri:noRegion>Bristol</wicri:noRegion></affiliation></author><author><name sortKey="Lewis, Sarah J" sort="Lewis, Sarah J" uniqKey="Lewis S" first="Sarah J." last="Lewis">Sarah J. Lewis</name><affiliation wicri:level="1"><nlm:aff id="Aff1">School of Social and Community Medicine, University of Bristol, Bristol, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>School of Social and Community Medicine, University of Bristol, Bristol</wicri:regionArea><wicri:noRegion>Bristol</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff2">MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Integrative Epidemiology Unit at the University of Bristol, Bristol</wicri:regionArea><wicri:noRegion>Bristol</wicri:noRegion></affiliation></author><author><name sortKey="Martin, Richard M" sort="Martin, Richard M" uniqKey="Martin R" first="Richard M." last="Martin">Richard M. Martin</name><affiliation wicri:level="1"><nlm:aff id="Aff1">School of Social and Community Medicine, University of Bristol, Bristol, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>School of Social and Community Medicine, University of Bristol, Bristol</wicri:regionArea><wicri:noRegion>Bristol</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff2">MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Integrative Epidemiology Unit at the University of Bristol, Bristol</wicri:regionArea><wicri:noRegion>Bristol</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff3">National Institute for Health Research, Bristol Biomedical Research Unit in Nutrition, Bristol, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>National Institute for Health Research, Bristol Biomedical Research Unit in Nutrition, Bristol</wicri:regionArea><wicri:noRegion>Bristol</wicri:noRegion></affiliation></author><author><name sortKey="Donovan, Jenny L" sort="Donovan, Jenny L" uniqKey="Donovan J" first="Jenny L." last="Donovan">Jenny L. Donovan</name><affiliation wicri:level="1"><nlm:aff id="Aff1">School of Social and Community Medicine, University of Bristol, Bristol, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>School of Social and Community Medicine, University of Bristol, Bristol</wicri:regionArea><wicri:noRegion>Bristol</wicri:noRegion></affiliation></author><author><name sortKey="Hamdy, Freddie C" sort="Hamdy, Freddie C" uniqKey="Hamdy F" first="Freddie C." last="Hamdy">Freddie C. Hamdy</name><affiliation wicri:level="4"><nlm:aff id="Aff4">Nuffield Department of Surgery, University of Oxford, Oxford, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Nuffield Department of Surgery, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Neal, David E" sort="Neal, David E" uniqKey="Neal D" first="David E." last="Neal">David E. Neal</name><affiliation wicri:level="4"><nlm:aff id="Aff4">Nuffield Department of Surgery, University of Oxford, Oxford, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Nuffield Department of Surgery, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation><affiliation wicri:level="4"><nlm:aff id="Aff5">Surgical Oncology (Uro-Oncology: S4), University of Cambridge, Box 279, Addenbrooke’s Hospital, Hills Road, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Surgical Oncology (Uro-Oncology: S4), University of Cambridge, Box 279, Addenbrooke’s Hospital, Hills Road, Cambridge</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Eeles, Rosalind" sort="Eeles, Rosalind" uniqKey="Eeles R" first="Rosalind" last="Eeles">Rosalind Eeles</name><affiliation><nlm:aff id="Aff6">The Institute of Cancer Research, 15 Cotswold Road, Sutton, SM2 5NG Surrey UK</nlm:aff><wicri:noCountry code="subfield">SM2 5NG Surrey UK</wicri:noCountry></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff7">The Royal Marsden NHS Foundation Trust, Fulham and Sutton London and Surrey, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The Royal Marsden NHS Foundation Trust, Fulham and Sutton London and Surrey</wicri:regionArea><wicri:noRegion>Fulham and Sutton London and Surrey</wicri:noRegion></affiliation></author><author><name sortKey="Easton, Doug" sort="Easton, Doug" uniqKey="Easton D" first="Doug" last="Easton">Doug Easton</name><affiliation wicri:level="4"><nlm:aff id="Aff8">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Worts Causeway Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Worts Causeway Cambridge</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Kote Jarai, Zsofia" sort="Kote Jarai, Zsofia" uniqKey="Kote Jarai Z" first="Zsofia" last="Kote-Jarai">Zsofia Kote-Jarai</name><affiliation><nlm:aff id="Aff6">The Institute of Cancer Research, 15 Cotswold Road, Sutton, SM2 5NG Surrey UK</nlm:aff><wicri:noCountry code="subfield">SM2 5NG Surrey UK</wicri:noCountry></affiliation></author><author><name sortKey="Al Olama, Ali Amin" sort="Al Olama, Ali Amin" uniqKey="Al Olama A" first="Ali Amin" last="Al Olama">Ali Amin Al Olama</name><affiliation wicri:level="4"><nlm:aff id="Aff8">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Worts Causeway Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Worts Causeway Cambridge</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Benlloch, Sara" sort="Benlloch, Sara" uniqKey="Benlloch S" first="Sara" last="Benlloch">Sara Benlloch</name><affiliation wicri:level="4"><nlm:aff id="Aff8">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Worts Causeway Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Worts Causeway Cambridge</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Muir, Kenneth" sort="Muir, Kenneth" uniqKey="Muir K" first="Kenneth" last="Muir">Kenneth Muir</name><affiliation wicri:level="1"><nlm:aff id="Aff9">University of Warwick, Coventry, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University of Warwick, Coventry</wicri:regionArea><wicri:noRegion>Coventry</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="Aff10">Institute of Population Health, The University of Manchester, Manchester, M13 9PL UK</nlm:aff><orgName type="university">Université de Manchester</orgName><country>Royaume-Uni</country><placeName><settlement type="city">Manchester</settlement><region type="nation">Angleterre</region><region nuts="2" type="region">Grand Manchester</region></placeName></affiliation></author><author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G." last="Giles">Graham G. Giles</name><affiliation><nlm:aff id="Aff11">The Cancer Council Victoria, 615 St. Kilda Road, Melbourne, Victoria 3004 Australia</nlm:aff><wicri:noCountry code="subfield">Victoria 3004 Australia</wicri:noCountry></affiliation><affiliation wicri:level="4"><nlm:aff id="Aff12">Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria 3010 Australia</nlm:aff><orgName type="university">Université de Melbourne</orgName><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Wiklund, Fredrik" sort="Wiklund, Fredrik" uniqKey="Wiklund F" first="Fredrik" last="Wiklund">Fredrik Wiklund</name><affiliation wicri:level="3"><nlm:aff id="Aff13">Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Gronberg, Henrik" sort="Gronberg, Henrik" uniqKey="Gronberg H" first="Henrik" last="Gronberg">Henrik Gronberg</name><affiliation wicri:level="3"><nlm:aff id="Aff13">Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Haiman, Christopher A" sort="Haiman, Christopher A" uniqKey="Haiman C" first="Christopher A." last="Haiman">Christopher A. Haiman</name><affiliation wicri:level="2"><nlm:aff id="Aff14">Department of Preventive Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, CA USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Preventive Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Schleutker, Johanna" sort="Schleutker, Johanna" uniqKey="Schleutker J" first="Johanna" last="Schleutker">Johanna Schleutker</name><affiliation wicri:level="4"><nlm:aff id="Aff15">Department of Medical Biochemistry and Genetics, University of Turku, Turku, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Medical Biochemistry and Genetics, University of Turku, Turku</wicri:regionArea><placeName><settlement type="city">Turku</settlement><region type="région" nuts="2">Finlande occidentale</region><settlement type="city">Turku</settlement></placeName><orgName type="university">Université de Turku</orgName></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff16">Institute of Biomedical Technology/BioMediTech, University of Tampere and FimLab Laboratories, Tampere, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute of Biomedical Technology/BioMediTech, University of Tampere and FimLab Laboratories, Tampere</wicri:regionArea><wicri:noRegion>Tampere</wicri:noRegion></affiliation></author><author><name sortKey="Nordestgaard, B Rge G" sort="Nordestgaard, B Rge G" uniqKey="Nordestgaard B" first="B Rge G." last="Nordestgaard">B Rge G. Nordestgaard</name><affiliation><nlm:aff id="Aff17">Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev Ringvej 75, Herlev, DK-2730 Denmark</nlm:aff><wicri:noCountry code="subfield">DK-2730 Denmark</wicri:noCountry></affiliation></author><author><name sortKey="Travis, Ruth C" sort="Travis, Ruth C" uniqKey="Travis R" first="Ruth C." last="Travis">Ruth C. Travis</name><affiliation wicri:level="4"><nlm:aff id="Aff18">Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Pashayan, Nora" sort="Pashayan, Nora" uniqKey="Pashayan N" first="Nora" last="Pashayan">Nora Pashayan</name><affiliation wicri:level="4"><nlm:aff id="Aff19">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway Cambridge</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="Aff20">Department of Applied Health Research, University College London, 1-19 Torrington Place, London, WC1E 7HB UK</nlm:aff><orgName type="university">University College de Londres</orgName><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Khaw, Kay Tee" sort="Khaw, Kay Tee" uniqKey="Khaw K" first="Kay-Tee" last="Khaw">Kay-Tee Khaw</name><affiliation wicri:level="4"><nlm:aff id="Aff21">Cambridge Institute of Public Health, University of Cambridge, Forvie Site, Robinson Way, Cambridge, CB2 0SR UK</nlm:aff><orgName type="university">Université de Cambridge</orgName><country>Royaume-Uni</country><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Stanford, Janet L" sort="Stanford, Janet L" uniqKey="Stanford J" first="Janet L." last="Stanford">Janet L. Stanford</name><affiliation wicri:level="2"><nlm:aff id="Aff22">Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="Aff23">Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Department of Epidemiology, School of Public Health, University of Washington, Seattle</wicri:cityArea></affiliation></author><author><name sortKey="Blot, William J" sort="Blot, William J" uniqKey="Blot W" first="William J." last="Blot">William J. Blot</name><affiliation wicri:level="2"><nlm:aff id="Aff24">International Epidemiology Institute, 1455 Research Blvd., Suite 550, Rockville, MD 20850 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>International Epidemiology Institute, 1455 Research Blvd., Suite 550, Rockville</wicri:cityArea></affiliation></author><author><name sortKey="Thibodeau, Stephen" sort="Thibodeau, Stephen" uniqKey="Thibodeau S" first="Stephen" last="Thibodeau">Stephen Thibodeau</name><affiliation wicri:level="2"><nlm:aff id="Aff25">Mayo Clinic, Rochester, MN USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>Mayo Clinic, Rochester</wicri:cityArea></affiliation></author><author><name sortKey="Maier, Christiane" sort="Maier, Christiane" uniqKey="Maier C" first="Christiane" last="Maier">Christiane Maier</name><affiliation wicri:level="3"><nlm:aff id="Aff26">Department of Urology, University Hospital Ulm, Ulm, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Urology, University Hospital Ulm, Ulm</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Ulm</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="Aff27">Institute of Human Genetics, University Hospital Ulm, Ulm, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Human Genetics, University Hospital Ulm, Ulm</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Ulm</settlement></placeName></affiliation></author><author><name sortKey="Kibel, Adam S" sort="Kibel, Adam S" uniqKey="Kibel A" first="Adam S." last="Kibel">Adam S. Kibel</name><affiliation wicri:level="2"><nlm:aff id="Aff28">Brigham and Women’s Hospital/Dana-Farber Cancer Institute, 45 Francis Street - ASB II-3, Boston, MA 02115 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Brigham and Women’s Hospital/Dana-Farber Cancer Institute, 45 Francis Street - ASB II-3, Boston</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="Aff29">Washington University, St Louis, MO USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Missouri (État)</region></placeName><wicri:cityArea>Washington University, St Louis</wicri:cityArea></affiliation></author><author><name sortKey="Cybulski, Cezary" sort="Cybulski, Cezary" uniqKey="Cybulski C" first="Cezary" last="Cybulski">Cezary Cybulski</name><affiliation wicri:level="1"><nlm:aff id="Aff30">International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin</wicri:regionArea><wicri:noRegion>Szczecin</wicri:noRegion></affiliation></author><author><name sortKey="Cannon Albright, Lisa" sort="Cannon Albright, Lisa" uniqKey="Cannon Albright L" first="Lisa" last="Cannon-Albright">Lisa Cannon-Albright</name><affiliation wicri:level="2"><nlm:aff id="Aff31">Division of Genetic Epidemiology, Department of Medicine, University of Utah School of Medicine, Salt Lake City, UT USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Utah</region></placeName><wicri:cityArea>Division of Genetic Epidemiology, Department of Medicine, University of Utah School of Medicine, Salt Lake City</wicri:cityArea></affiliation></author><author><name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name><affiliation wicri:level="3"><nlm:aff id="Aff32">Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="Aff33">Division of Preventive Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Preventive Oncology, German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="Aff34">German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Park, Jong" sort="Park, Jong" uniqKey="Park J" first="Jong" last="Park">Jong Park</name><affiliation wicri:level="2"><nlm:aff id="Aff35">Division of Cancer Prevention and Control, H. Lee Moffitt Cancer Center, 12902 Magnolia Dr., Tampa, FL USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Division of Cancer Prevention and Control, H. Lee Moffitt Cancer Center, 12902 Magnolia Dr., Tampa</wicri:cityArea></affiliation></author><author><name sortKey="Kaneva, Radka" sort="Kaneva, Radka" uniqKey="Kaneva R" first="Radka" last="Kaneva">Radka Kaneva</name><affiliation wicri:level="3"><nlm:aff id="Aff36">Molecular Medicine Center and Department of Medical Chemistry and Biochemistry, Medical University-Sofia, 2 Zdrave St., Sofia, 1431 Bulgaria</nlm:aff><country xml:lang="fr">Bulgarie</country><wicri:regionArea>Molecular Medicine Center and Department of Medical Chemistry and Biochemistry, Medical University-Sofia, 2 Zdrave St., Sofia</wicri:regionArea><placeName><settlement type="city">Sofia</settlement><region nuts="2">Sofia-ville (oblast)</region></placeName></affiliation></author><author><name sortKey="Batra, Jyotsna" sort="Batra, Jyotsna" uniqKey="Batra J" first="Jyotsna" last="Batra">Jyotsna Batra</name><affiliation wicri:level="1"><nlm:aff id="Aff37">Australian Prostate Cancer Research Centre – Qld, Institute of Health and Biomedical Innovation and School of Biomedical Sciences, Queensland University of Technology, Brisbane, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Australian Prostate Cancer Research Centre – Qld, Institute of Health and Biomedical Innovation and School of Biomedical Sciences, Queensland University of Technology, Brisbane</wicri:regionArea><wicri:noRegion>Brisbane</wicri:noRegion></affiliation></author><author><name sortKey="Teixeira, Manuel R" sort="Teixeira, Manuel R" uniqKey="Teixeira M" first="Manuel R." last="Teixeira">Manuel R. Teixeira</name><affiliation wicri:level="1"><nlm:aff id="Aff38">Department of Genetics, Portuguese Oncology Institute, Porto, Portugal</nlm:aff><country xml:lang="fr">Portugal</country><wicri:regionArea>Department of Genetics, Portuguese Oncology Institute, Porto</wicri:regionArea><wicri:noRegion>Porto</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff39">Biomedical Sciences Institute (ICBAS), Porto University, Porto, Portugal</nlm:aff><country xml:lang="fr">Portugal</country><wicri:regionArea>Biomedical Sciences Institute (ICBAS), Porto University, Porto</wicri:regionArea><wicri:noRegion>Porto</wicri:noRegion></affiliation></author><author><name sortKey="Pandha, Hardev" sort="Pandha, Hardev" uniqKey="Pandha H" first="Hardev" last="Pandha">Hardev Pandha</name><affiliation><nlm:aff id="Aff40">The University of Surrey, Guildford, Surrey GU2 7XH UK</nlm:aff><wicri:noCountry code="subfield">Surrey GU2 7XH UK</wicri:noCountry></affiliation></author><author><name sortKey="Lathrop, Mark" sort="Lathrop, Mark" uniqKey="Lathrop M" first="Mark" last="Lathrop">Mark Lathrop</name><affiliation wicri:level="3"><nlm:aff id="Aff41">Commissariat à l’Energie Atomique, Center National de Génotypage, Evry, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Commissariat à l’Energie Atomique, Center National de Génotypage, Evry</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Évry (Essonne)</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="Aff42">McGill University-Génome Québec Innovation Centre, Montreal, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>McGill University-Génome Québec Innovation Centre, Montreal</wicri:regionArea><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation></author><author><name sortKey="Davey Smith, George" sort="Davey Smith, George" uniqKey="Davey Smith G" first="George" last="Davey Smith">George Davey Smith</name><affiliation wicri:level="1"><nlm:aff id="Aff1">School of Social and Community Medicine, University of Bristol, Bristol, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>School of Social and Community Medicine, University of Bristol, Bristol</wicri:regionArea><wicri:noRegion>Bristol</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff2">MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Integrative Epidemiology Unit at the University of Bristol, Bristol</wicri:regionArea><wicri:noRegion>Bristol</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27044414</idno><idno type="pmc">4820939</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4820939</idno><idno type="RBID">PMC:4820939</idno><idno type="doi">10.1186/s12916-016-0602-x</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">000B03</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000B03</idno><idno type="wicri:Area/Pmc/Curation">000A80</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000A80</idno><idno type="wicri:Area/Pmc/Checkpoint">000671</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000671</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">001F84</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001F84</idno><idno type="wicri:Area/PubMed/Curation">001F59</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001F59</idno><idno type="wicri:Area/PubMed/Checkpoint">001F59</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001F59</idno><idno type="wicri:Area/Ncbi/Merge">003362</idno><idno type="wicri:Area/Ncbi/Curation">003362</idno><idno type="wicri:Area/Ncbi/Checkpoint">003362</idno><idno type="wicri:Area/Main/Merge">001871</idno><idno type="wicri:Area/Main/Curation">001876</idno><idno type="wicri:Area/Main/Exploration">001876</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Pubertal development and prostate cancer risk: Mendelian randomization study in a population-based cohort</title><author><name sortKey="Bonilla, Carolina" sort="Bonilla, Carolina" uniqKey="Bonilla C" first="Carolina" last="Bonilla">Carolina Bonilla</name><affiliation wicri:level="1"><nlm:aff id="Aff1">School of Social and Community Medicine, University of Bristol, Bristol, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>School of Social and Community Medicine, University of Bristol, Bristol</wicri:regionArea><wicri:noRegion>Bristol</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff2">MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Integrative Epidemiology Unit at the University of Bristol, Bristol</wicri:regionArea><wicri:noRegion>Bristol</wicri:noRegion></affiliation></author><author><name sortKey="Lewis, Sarah J" sort="Lewis, Sarah J" uniqKey="Lewis S" first="Sarah J." last="Lewis">Sarah J. Lewis</name><affiliation wicri:level="1"><nlm:aff id="Aff1">School of Social and Community Medicine, University of Bristol, Bristol, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>School of Social and Community Medicine, University of Bristol, Bristol</wicri:regionArea><wicri:noRegion>Bristol</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff2">MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Integrative Epidemiology Unit at the University of Bristol, Bristol</wicri:regionArea><wicri:noRegion>Bristol</wicri:noRegion></affiliation></author><author><name sortKey="Martin, Richard M" sort="Martin, Richard M" uniqKey="Martin R" first="Richard M." last="Martin">Richard M. Martin</name><affiliation wicri:level="1"><nlm:aff id="Aff1">School of Social and Community Medicine, University of Bristol, Bristol, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>School of Social and Community Medicine, University of Bristol, Bristol</wicri:regionArea><wicri:noRegion>Bristol</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff2">MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Integrative Epidemiology Unit at the University of Bristol, Bristol</wicri:regionArea><wicri:noRegion>Bristol</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff3">National Institute for Health Research, Bristol Biomedical Research Unit in Nutrition, Bristol, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>National Institute for Health Research, Bristol Biomedical Research Unit in Nutrition, Bristol</wicri:regionArea><wicri:noRegion>Bristol</wicri:noRegion></affiliation></author><author><name sortKey="Donovan, Jenny L" sort="Donovan, Jenny L" uniqKey="Donovan J" first="Jenny L." last="Donovan">Jenny L. Donovan</name><affiliation wicri:level="1"><nlm:aff id="Aff1">School of Social and Community Medicine, University of Bristol, Bristol, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>School of Social and Community Medicine, University of Bristol, Bristol</wicri:regionArea><wicri:noRegion>Bristol</wicri:noRegion></affiliation></author><author><name sortKey="Hamdy, Freddie C" sort="Hamdy, Freddie C" uniqKey="Hamdy F" first="Freddie C." last="Hamdy">Freddie C. Hamdy</name><affiliation wicri:level="4"><nlm:aff id="Aff4">Nuffield Department of Surgery, University of Oxford, Oxford, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Nuffield Department of Surgery, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Neal, David E" sort="Neal, David E" uniqKey="Neal D" first="David E." last="Neal">David E. Neal</name><affiliation wicri:level="4"><nlm:aff id="Aff4">Nuffield Department of Surgery, University of Oxford, Oxford, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Nuffield Department of Surgery, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation><affiliation wicri:level="4"><nlm:aff id="Aff5">Surgical Oncology (Uro-Oncology: S4), University of Cambridge, Box 279, Addenbrooke’s Hospital, Hills Road, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Surgical Oncology (Uro-Oncology: S4), University of Cambridge, Box 279, Addenbrooke’s Hospital, Hills Road, Cambridge</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Eeles, Rosalind" sort="Eeles, Rosalind" uniqKey="Eeles R" first="Rosalind" last="Eeles">Rosalind Eeles</name><affiliation><nlm:aff id="Aff6">The Institute of Cancer Research, 15 Cotswold Road, Sutton, SM2 5NG Surrey UK</nlm:aff><wicri:noCountry code="subfield">SM2 5NG Surrey UK</wicri:noCountry></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff7">The Royal Marsden NHS Foundation Trust, Fulham and Sutton London and Surrey, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The Royal Marsden NHS Foundation Trust, Fulham and Sutton London and Surrey</wicri:regionArea><wicri:noRegion>Fulham and Sutton London and Surrey</wicri:noRegion></affiliation></author><author><name sortKey="Easton, Doug" sort="Easton, Doug" uniqKey="Easton D" first="Doug" last="Easton">Doug Easton</name><affiliation wicri:level="4"><nlm:aff id="Aff8">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Worts Causeway Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Worts Causeway Cambridge</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Kote Jarai, Zsofia" sort="Kote Jarai, Zsofia" uniqKey="Kote Jarai Z" first="Zsofia" last="Kote-Jarai">Zsofia Kote-Jarai</name><affiliation><nlm:aff id="Aff6">The Institute of Cancer Research, 15 Cotswold Road, Sutton, SM2 5NG Surrey UK</nlm:aff><wicri:noCountry code="subfield">SM2 5NG Surrey UK</wicri:noCountry></affiliation></author><author><name sortKey="Al Olama, Ali Amin" sort="Al Olama, Ali Amin" uniqKey="Al Olama A" first="Ali Amin" last="Al Olama">Ali Amin Al Olama</name><affiliation wicri:level="4"><nlm:aff id="Aff8">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Worts Causeway Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Worts Causeway Cambridge</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Benlloch, Sara" sort="Benlloch, Sara" uniqKey="Benlloch S" first="Sara" last="Benlloch">Sara Benlloch</name><affiliation wicri:level="4"><nlm:aff id="Aff8">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Worts Causeway Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Worts Causeway Cambridge</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Muir, Kenneth" sort="Muir, Kenneth" uniqKey="Muir K" first="Kenneth" last="Muir">Kenneth Muir</name><affiliation wicri:level="1"><nlm:aff id="Aff9">University of Warwick, Coventry, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University of Warwick, Coventry</wicri:regionArea><wicri:noRegion>Coventry</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="Aff10">Institute of Population Health, The University of Manchester, Manchester, M13 9PL UK</nlm:aff><orgName type="university">Université de Manchester</orgName><country>Royaume-Uni</country><placeName><settlement type="city">Manchester</settlement><region type="nation">Angleterre</region><region nuts="2" type="region">Grand Manchester</region></placeName></affiliation></author><author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G." last="Giles">Graham G. Giles</name><affiliation><nlm:aff id="Aff11">The Cancer Council Victoria, 615 St. Kilda Road, Melbourne, Victoria 3004 Australia</nlm:aff><wicri:noCountry code="subfield">Victoria 3004 Australia</wicri:noCountry></affiliation><affiliation wicri:level="4"><nlm:aff id="Aff12">Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria 3010 Australia</nlm:aff><orgName type="university">Université de Melbourne</orgName><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Wiklund, Fredrik" sort="Wiklund, Fredrik" uniqKey="Wiklund F" first="Fredrik" last="Wiklund">Fredrik Wiklund</name><affiliation wicri:level="3"><nlm:aff id="Aff13">Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Gronberg, Henrik" sort="Gronberg, Henrik" uniqKey="Gronberg H" first="Henrik" last="Gronberg">Henrik Gronberg</name><affiliation wicri:level="3"><nlm:aff id="Aff13">Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Haiman, Christopher A" sort="Haiman, Christopher A" uniqKey="Haiman C" first="Christopher A." last="Haiman">Christopher A. Haiman</name><affiliation wicri:level="2"><nlm:aff id="Aff14">Department of Preventive Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, CA USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Preventive Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Schleutker, Johanna" sort="Schleutker, Johanna" uniqKey="Schleutker J" first="Johanna" last="Schleutker">Johanna Schleutker</name><affiliation wicri:level="4"><nlm:aff id="Aff15">Department of Medical Biochemistry and Genetics, University of Turku, Turku, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Medical Biochemistry and Genetics, University of Turku, Turku</wicri:regionArea><placeName><settlement type="city">Turku</settlement><region type="région" nuts="2">Finlande occidentale</region><settlement type="city">Turku</settlement></placeName><orgName type="university">Université de Turku</orgName></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff16">Institute of Biomedical Technology/BioMediTech, University of Tampere and FimLab Laboratories, Tampere, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute of Biomedical Technology/BioMediTech, University of Tampere and FimLab Laboratories, Tampere</wicri:regionArea><wicri:noRegion>Tampere</wicri:noRegion></affiliation></author><author><name sortKey="Nordestgaard, B Rge G" sort="Nordestgaard, B Rge G" uniqKey="Nordestgaard B" first="B Rge G." last="Nordestgaard">B Rge G. Nordestgaard</name><affiliation><nlm:aff id="Aff17">Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev Ringvej 75, Herlev, DK-2730 Denmark</nlm:aff><wicri:noCountry code="subfield">DK-2730 Denmark</wicri:noCountry></affiliation></author><author><name sortKey="Travis, Ruth C" sort="Travis, Ruth C" uniqKey="Travis R" first="Ruth C." last="Travis">Ruth C. Travis</name><affiliation wicri:level="4"><nlm:aff id="Aff18">Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Pashayan, Nora" sort="Pashayan, Nora" uniqKey="Pashayan N" first="Nora" last="Pashayan">Nora Pashayan</name><affiliation wicri:level="4"><nlm:aff id="Aff19">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway Cambridge</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="Aff20">Department of Applied Health Research, University College London, 1-19 Torrington Place, London, WC1E 7HB UK</nlm:aff><orgName type="university">University College de Londres</orgName><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Khaw, Kay Tee" sort="Khaw, Kay Tee" uniqKey="Khaw K" first="Kay-Tee" last="Khaw">Kay-Tee Khaw</name><affiliation wicri:level="4"><nlm:aff id="Aff21">Cambridge Institute of Public Health, University of Cambridge, Forvie Site, Robinson Way, Cambridge, CB2 0SR UK</nlm:aff><orgName type="university">Université de Cambridge</orgName><country>Royaume-Uni</country><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Stanford, Janet L" sort="Stanford, Janet L" uniqKey="Stanford J" first="Janet L." last="Stanford">Janet L. Stanford</name><affiliation wicri:level="2"><nlm:aff id="Aff22">Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="Aff23">Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Department of Epidemiology, School of Public Health, University of Washington, Seattle</wicri:cityArea></affiliation></author><author><name sortKey="Blot, William J" sort="Blot, William J" uniqKey="Blot W" first="William J." last="Blot">William J. Blot</name><affiliation wicri:level="2"><nlm:aff id="Aff24">International Epidemiology Institute, 1455 Research Blvd., Suite 550, Rockville, MD 20850 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>International Epidemiology Institute, 1455 Research Blvd., Suite 550, Rockville</wicri:cityArea></affiliation></author><author><name sortKey="Thibodeau, Stephen" sort="Thibodeau, Stephen" uniqKey="Thibodeau S" first="Stephen" last="Thibodeau">Stephen Thibodeau</name><affiliation wicri:level="2"><nlm:aff id="Aff25">Mayo Clinic, Rochester, MN USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>Mayo Clinic, Rochester</wicri:cityArea></affiliation></author><author><name sortKey="Maier, Christiane" sort="Maier, Christiane" uniqKey="Maier C" first="Christiane" last="Maier">Christiane Maier</name><affiliation wicri:level="3"><nlm:aff id="Aff26">Department of Urology, University Hospital Ulm, Ulm, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Urology, University Hospital Ulm, Ulm</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Ulm</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="Aff27">Institute of Human Genetics, University Hospital Ulm, Ulm, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Human Genetics, University Hospital Ulm, Ulm</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Ulm</settlement></placeName></affiliation></author><author><name sortKey="Kibel, Adam S" sort="Kibel, Adam S" uniqKey="Kibel A" first="Adam S." last="Kibel">Adam S. Kibel</name><affiliation wicri:level="2"><nlm:aff id="Aff28">Brigham and Women’s Hospital/Dana-Farber Cancer Institute, 45 Francis Street - ASB II-3, Boston, MA 02115 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Brigham and Women’s Hospital/Dana-Farber Cancer Institute, 45 Francis Street - ASB II-3, Boston</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="Aff29">Washington University, St Louis, MO USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Missouri (État)</region></placeName><wicri:cityArea>Washington University, St Louis</wicri:cityArea></affiliation></author><author><name sortKey="Cybulski, Cezary" sort="Cybulski, Cezary" uniqKey="Cybulski C" first="Cezary" last="Cybulski">Cezary Cybulski</name><affiliation wicri:level="1"><nlm:aff id="Aff30">International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin</wicri:regionArea><wicri:noRegion>Szczecin</wicri:noRegion></affiliation></author><author><name sortKey="Cannon Albright, Lisa" sort="Cannon Albright, Lisa" uniqKey="Cannon Albright L" first="Lisa" last="Cannon-Albright">Lisa Cannon-Albright</name><affiliation wicri:level="2"><nlm:aff id="Aff31">Division of Genetic Epidemiology, Department of Medicine, University of Utah School of Medicine, Salt Lake City, UT USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Utah</region></placeName><wicri:cityArea>Division of Genetic Epidemiology, Department of Medicine, University of Utah School of Medicine, Salt Lake City</wicri:cityArea></affiliation></author><author><name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name><affiliation wicri:level="3"><nlm:aff id="Aff32">Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="Aff33">Division of Preventive Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Preventive Oncology, German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="Aff34">German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Park, Jong" sort="Park, Jong" uniqKey="Park J" first="Jong" last="Park">Jong Park</name><affiliation wicri:level="2"><nlm:aff id="Aff35">Division of Cancer Prevention and Control, H. Lee Moffitt Cancer Center, 12902 Magnolia Dr., Tampa, FL USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Division of Cancer Prevention and Control, H. Lee Moffitt Cancer Center, 12902 Magnolia Dr., Tampa</wicri:cityArea></affiliation></author><author><name sortKey="Kaneva, Radka" sort="Kaneva, Radka" uniqKey="Kaneva R" first="Radka" last="Kaneva">Radka Kaneva</name><affiliation wicri:level="3"><nlm:aff id="Aff36">Molecular Medicine Center and Department of Medical Chemistry and Biochemistry, Medical University-Sofia, 2 Zdrave St., Sofia, 1431 Bulgaria</nlm:aff><country xml:lang="fr">Bulgarie</country><wicri:regionArea>Molecular Medicine Center and Department of Medical Chemistry and Biochemistry, Medical University-Sofia, 2 Zdrave St., Sofia</wicri:regionArea><placeName><settlement type="city">Sofia</settlement><region nuts="2">Sofia-ville (oblast)</region></placeName></affiliation></author><author><name sortKey="Batra, Jyotsna" sort="Batra, Jyotsna" uniqKey="Batra J" first="Jyotsna" last="Batra">Jyotsna Batra</name><affiliation wicri:level="1"><nlm:aff id="Aff37">Australian Prostate Cancer Research Centre – Qld, Institute of Health and Biomedical Innovation and School of Biomedical Sciences, Queensland University of Technology, Brisbane, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Australian Prostate Cancer Research Centre – Qld, Institute of Health and Biomedical Innovation and School of Biomedical Sciences, Queensland University of Technology, Brisbane</wicri:regionArea><wicri:noRegion>Brisbane</wicri:noRegion></affiliation></author><author><name sortKey="Teixeira, Manuel R" sort="Teixeira, Manuel R" uniqKey="Teixeira M" first="Manuel R." last="Teixeira">Manuel R. Teixeira</name><affiliation wicri:level="1"><nlm:aff id="Aff38">Department of Genetics, Portuguese Oncology Institute, Porto, Portugal</nlm:aff><country xml:lang="fr">Portugal</country><wicri:regionArea>Department of Genetics, Portuguese Oncology Institute, Porto</wicri:regionArea><wicri:noRegion>Porto</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff39">Biomedical Sciences Institute (ICBAS), Porto University, Porto, Portugal</nlm:aff><country xml:lang="fr">Portugal</country><wicri:regionArea>Biomedical Sciences Institute (ICBAS), Porto University, Porto</wicri:regionArea><wicri:noRegion>Porto</wicri:noRegion></affiliation></author><author><name sortKey="Pandha, Hardev" sort="Pandha, Hardev" uniqKey="Pandha H" first="Hardev" last="Pandha">Hardev Pandha</name><affiliation><nlm:aff id="Aff40">The University of Surrey, Guildford, Surrey GU2 7XH UK</nlm:aff><wicri:noCountry code="subfield">Surrey GU2 7XH UK</wicri:noCountry></affiliation></author><author><name sortKey="Lathrop, Mark" sort="Lathrop, Mark" uniqKey="Lathrop M" first="Mark" last="Lathrop">Mark Lathrop</name><affiliation wicri:level="3"><nlm:aff id="Aff41">Commissariat à l’Energie Atomique, Center National de Génotypage, Evry, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Commissariat à l’Energie Atomique, Center National de Génotypage, Evry</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Évry (Essonne)</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="Aff42">McGill University-Génome Québec Innovation Centre, Montreal, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>McGill University-Génome Québec Innovation Centre, Montreal</wicri:regionArea><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation></author><author><name sortKey="Davey Smith, George" sort="Davey Smith, George" uniqKey="Davey Smith G" first="George" last="Davey Smith">George Davey Smith</name><affiliation wicri:level="1"><nlm:aff id="Aff1">School of Social and Community Medicine, University of Bristol, Bristol, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>School of Social and Community Medicine, University of Bristol, Bristol</wicri:regionArea><wicri:noRegion>Bristol</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff2">MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Integrative Epidemiology Unit at the University of Bristol, Bristol</wicri:regionArea><wicri:noRegion>Bristol</wicri:noRegion></affiliation></author></analytic><series><title level="j">BMC Medicine</title><idno type="eISSN">1741-7015</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Age of Onset</term><term>Aged</term><term>Case-Control Studies</term><term>Genome-Wide Association Study</term><term>Humans</term><term>Male</term><term>Mendelian Randomization Analysis (methods)</term><term>Middle Aged</term><term>Neoplasm Staging</term><term>Odds Ratio</term><term>Polymorphism, Single Nucleotide</term><term>Prostatic Neoplasms (epidemiology)</term><term>Prostatic Neoplasms (genetics)</term><term>Prostatic Neoplasms (pathology)</term><term>Prostatic Neoplasms (physiopathology)</term><term>Puberty (physiology)</term><term>Random Allocation</term><term>Regression Analysis</term><term>Risk Factors</term><term>Sexual Maturation (genetics)</term><term>Survival Analysis</term><term>United Kingdom (epidemiology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term><term>Adulte d'âge moyen</term><term>Analyse de randomisation mendélienne ()</term><term>Analyse de régression</term><term>Analyse de survie</term><term>Attribution aléatoire</term><term>Facteurs de risque</term><term>Humains</term><term>Maturation sexuelle (génétique)</term><term>Mâle</term><term>Odds ratio</term><term>Polymorphisme de nucléotide simple</term><term>Puberté (physiologie)</term><term>Royaume-Uni (épidémiologie)</term><term>Stade de la tumeur</term><term>Sujet âgé</term><term>Tumeurs de la prostate (anatomopathologie)</term><term>Tumeurs de la prostate (génétique)</term><term>Tumeurs de la prostate (physiopathologie)</term><term>Tumeurs de la prostate (épidémiologie)</term><term>Âge de début</term><term>Étude d'association pangénomique</term><term>Études cas-témoins</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Tumeurs de la prostate</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Prostatic Neoplasms</term><term>United Kingdom</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Prostatic Neoplasms</term><term>Sexual Maturation</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Maturation sexuelle</term><term>Tumeurs de la prostate</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Mendelian Randomization Analysis</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Prostatic Neoplasms</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Puberté</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Puberty</term></keywords><keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Tumeurs de la prostate</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Prostatic Neoplasms</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Royaume-Uni</term><term>Tumeurs de la prostate</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Age of Onset</term><term>Aged</term><term>Case-Control Studies</term><term>Genome-Wide Association Study</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neoplasm Staging</term><term>Odds Ratio</term><term>Polymorphism, Single Nucleotide</term><term>Random Allocation</term><term>Regression Analysis</term><term>Risk Factors</term><term>Survival Analysis</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte d'âge moyen</term><term>Analyse de randomisation mendélienne</term><term>Analyse de régression</term><term>Analyse de survie</term><term>Attribution aléatoire</term><term>Facteurs de risque</term><term>Humains</term><term>Mâle</term><term>Odds ratio</term><term>Polymorphisme de nucléotide simple</term><term>Stade de la tumeur</term><term>Sujet âgé</term><term>Âge de début</term><term>Étude d'association pangénomique</term><term>Études cas-témoins</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Epidemiological studies have observed a positive association between an earlier age at sexual development and prostate cancer, but markers of sexual maturation in boys are imprecise and observational estimates are likely to suffer from a degree of uncontrolled confounding. To obtain causal estimates, we examined the role of pubertal development in prostate cancer using genetic polymorphisms associated with Tanner stage in adolescent boys in a Mendelian randomization (MR) approach.</p></sec><sec><title>Methods</title><p>We derived a weighted genetic risk score for pubertal development, combining 13 SNPs associated with male Tanner stage. A higher score indicated a later puberty onset. We examined the association of this score with prostate cancer risk, stage and grade in the UK-based ProtecT case-control study (<italic>n</italic> = 2,927), and used the PRACTICAL consortium (<italic>n</italic> = 43,737) as a replication sample.</p></sec><sec><title>Results</title><p>In ProtecT, the puberty genetic score was inversely associated with prostate cancer grade (odds ratio (OR) of high- vs. low-grade cancer, per tertile of the score: 0.76; 95 % CI, 0.64–0.89). In an instrumental variable estimation of the causal OR, later physical development in adolescence (equivalent to a difference of one Tanner stage between pubertal boys of the same age) was associated with a 77 % (95 % CI, 43–91 %) reduced odds of high Gleason prostate cancer. In PRACTICAL, the puberty genetic score was associated with prostate cancer stage (OR of advanced vs. localized cancer, per tertile: 0.95; 95 % CI, 0.91–1.00) and prostate cancer-specific mortality (hazard ratio amongst cases, per tertile: 0.94; 95 % CI, 0.90–0.98), but not with disease grade.</p></sec><sec><title>Conclusions</title><p>Older age at sexual maturation is causally linked to a reduced risk of later prostate cancer, especially aggressive disease.</p></sec><sec><title>Electronic supplementary material</title><p>The online version of this article (doi:10.1186/s12916-016-0602-x) contains supplementary material, which is available to authorized users.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Jemal, A" uniqKey="Jemal A">A Jemal</name></author><author><name sortKey="Bray, F" uniqKey="Bray F">F Bray</name></author><author><name sortKey="Center, Mm" uniqKey="Center M">MM Center</name></author><author><name sortKey="Ferlay, J" uniqKey="Ferlay J">J Ferlay</name></author><author><name sortKey="Ward, E" uniqKey="Ward E">E Ward</name></author><author><name sortKey="Forman, D" uniqKey="Forman D">D Forman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sakr, Wa" uniqKey="Sakr W">WA Sakr</name></author><author><name sortKey="Haas, Gp" uniqKey="Haas G">GP Haas</name></author><author><name sortKey="Cassin, Bf" uniqKey="Cassin B">BF Cassin</name></author><author><name sortKey="Pontes, Je" uniqKey="Pontes J">JE Pontes</name></author><author><name sortKey="Crissman, Jd" uniqKey="Crissman J">JD Crissman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sutcliffe, S" uniqKey="Sutcliffe S">S Sutcliffe</name></author><author><name sortKey="Colditz, Ga" uniqKey="Colditz G">GA Colditz</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Rowlands, M A" uniqKey="Rowlands M">M-A Rowlands</name></author><author><name sortKey="Gunnell, D" uniqKey="Gunnell D">D Gunnell</name></author><author><name sortKey="Harris, R" uniqKey="Harris R">R Harris</name></author><author><name sortKey="Vatten, Lj" uniqKey="Vatten L">LJ Vatten</name></author><author><name sortKey="Holly, Jmp" uniqKey="Holly J">JMP Holly</name></author><author><name sortKey="Martin, Rm" uniqKey="Martin R">RM Martin</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Tanner, Jm" uniqKey="Tanner J">JM Tanner</name></author><author><name sortKey="Whitehouse, Rh" uniqKey="Whitehouse R">RH Whitehouse</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Davey Smith, G" uniqKey="Davey Smith G">G Davey Smith</name></author><author><name sortKey="Ebrahim, S" uniqKey="Ebrahim S">S Ebrahim</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Lane, Ja" uniqKey="Lane J">JA Lane</name></author><author><name sortKey="Hamdy, Fc" uniqKey="Hamdy F">FC Hamdy</name></author><author><name sortKey="Martin, Rm" uniqKey="Martin R">RM Martin</name></author><author><name sortKey="Turner, El" uniqKey="Turner E">EL Turner</name></author><author><name sortKey="Neal, De" uniqKey="Neal D">DE Neal</name></author><author><name sortKey="Donovan, Jl" uniqKey="Donovan J">JL Donovan</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Ohori, M" uniqKey="Ohori M">M Ohori</name></author><author><name sortKey="Wheeler, Tm" uniqKey="Wheeler T">TM Wheeler</name></author><author><name sortKey="Scardino, Pt" uniqKey="Scardino P">PT Scardino</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Bowden, J" uniqKey="Bowden J">J Bowden</name></author><author><name sortKey="Davey Smith, G" uniqKey="Davey Smith G">G Davey Smith</name></author><author><name sortKey="Burgess, S" uniqKey="Burgess S">S Burgess</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Burgess, S" uniqKey="Burgess S">S Burgess</name></author><author><name sortKey="Scott, Ra" uniqKey="Scott R">RA Scott</name></author><author><name sortKey="Timpson, Nj" uniqKey="Timpson N">NJ Timpson</name></author><author><name sortKey="Davey Smith, G" uniqKey="Davey Smith G">G Davey Smith</name></author><author><name sortKey="Thompson, Sg" uniqKey="Thompson S">SG Thompson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lorentzon, M" uniqKey="Lorentzon M">M Lorentzon</name></author><author><name sortKey="Norjavaara, E" uniqKey="Norjavaara E">E Norjavaara</name></author><author><name sortKey="Kindblom, Jm" uniqKey="Kindblom J">JM Kindblom</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Albertsen, Pc" uniqKey="Albertsen P">PC Albertsen</name></author><author><name sortKey="Fryback, Dg" uniqKey="Fryback D">DG Fryback</name></author><author><name sortKey="Storer, Be" uniqKey="Storer B">BE Storer</name></author><author><name sortKey="Kolon, Tf" uniqKey="Kolon T">TF Kolon</name></author><author><name sortKey="Fine, J" uniqKey="Fine J">J Fine</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Habel, La" uniqKey="Habel L">LA Habel</name></author><author><name sortKey="Van Den Eeden, Sk" uniqKey="Van Den Eeden S">SK Van Den Eeden</name></author><author><name sortKey="Friedman, Gd" uniqKey="Friedman G">GD Friedman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Grossmann, M" uniqKey="Grossmann M">M Grossmann</name></author><author><name sortKey="Cheung, As" uniqKey="Cheung A">AS Cheung</name></author><author><name sortKey="Zajac, Jd" uniqKey="Zajac J">JD Zajac</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Sandhu, J" uniqKey="Sandhu J">J Sandhu</name></author><author><name sortKey="Davey Smith, G" uniqKey="Davey Smith G">G Davey Smith</name></author><author><name sortKey="Holly, J" uniqKey="Holly J">J Holly</name></author><author><name sortKey="Cole, Tj" uniqKey="Cole T">TJ Cole</name></author><author><name sortKey="Ben Shlomo, Y" uniqKey="Ben Shlomo Y">Y Ben-Shlomo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mcintyre, Mh" uniqKey="Mcintyre M">MH McIntyre</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rogers, I" uniqKey="Rogers I">I Rogers</name></author><author><name sortKey="Metcalfe, C" uniqKey="Metcalfe C">C Metcalfe</name></author><author><name sortKey="Gunnell, D" uniqKey="Gunnell D">D Gunnell</name></author><author><name sortKey="Emmett, P" uniqKey="Emmett P">P Emmett</name></author><author><name sortKey="Dunger, D" uniqKey="Dunger D">D Dunger</name></author><author><name sortKey="Holly, J" uniqKey="Holly J">J Holly</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Belsky, J" uniqKey="Belsky J">J Belsky</name></author><author><name sortKey="Steinberg, L" uniqKey="Steinberg L">L Steinberg</name></author><author><name sortKey="Draper, P" uniqKey="Draper P">P Draper</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Thomas, F" uniqKey="Thomas F">F Thomas</name></author><author><name sortKey="Elguero, E" uniqKey="Elguero E">E Elguero</name></author><author><name sortKey="Brodeur, J" uniqKey="Brodeur J">J Brodeur</name></author><author><name sortKey="Roche, B" uniqKey="Roche B">B Roche</name></author><author><name sortKey="Misse, D" uniqKey="Misse D">D Missé</name></author><author><name sortKey="Raymond, M" uniqKey="Raymond M">M Raymond</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Davey Smith, G" uniqKey="Davey Smith G">G Davey Smith</name></author><author><name sortKey="Hemani, G" uniqKey="Hemani G">G Hemani</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Velie, Em" uniqKey="Velie E">EM Velie</name></author><author><name sortKey="Nechuta, S" uniqKey="Nechuta S">S Nechuta</name></author><author><name sortKey="Osuch, Jr" uniqKey="Osuch J">JR Osuch</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Andersson, So" uniqKey="Andersson S">SO Andersson</name></author><author><name sortKey="Baron, J" uniqKey="Baron J">J Baron</name></author><author><name sortKey="Bergstrom, R" uniqKey="Bergstrom R">R Bergström</name></author><author><name sortKey="Lindgren, C" uniqKey="Lindgren C">C Lindgren</name></author><author><name sortKey="Wolk, A" uniqKey="Wolk A">A Wolk</name></author><author><name sortKey="Adami, Ho" uniqKey="Adami H">HO Adami</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Honda, Gd" uniqKey="Honda G">GD Honda</name></author><author><name sortKey="Bernstein, L" uniqKey="Bernstein L">L Bernstein</name></author><author><name sortKey="Ross, Rk" uniqKey="Ross R">RK Ross</name></author><author><name sortKey="Greenland, S" uniqKey="Greenland S">S Greenland</name></author><author><name sortKey="Gerkins, V" uniqKey="Gerkins V">V Gerkins</name></author><author><name sortKey="Henderson, Be" uniqKey="Henderson B">BE Henderson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schuman, Lm" uniqKey="Schuman L">LM Schuman</name></author><author><name sortKey="Mandel, J" uniqKey="Mandel J">J Mandel</name></author><author><name sortKey="Blackard, C" uniqKey="Blackard C">C Blackard</name></author><author><name sortKey="Bauer, H" uniqKey="Bauer H">H Bauer</name></author><author><name sortKey="Scarlett, J" uniqKey="Scarlett J">J Scarlett</name></author><author><name sortKey="Mchugh, R" uniqKey="Mchugh R">R McHugh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dennis, Lk" uniqKey="Dennis L">LK Dennis</name></author><author><name sortKey="Dawson, Dv" uniqKey="Dawson D">DV Dawson</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Bulgarie</li><li>Canada</li><li>Finlande</li><li>France</li><li>Pologne</li><li>Portugal</li><li>Royaume-Uni</li><li>Suède</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Angleterre de l'Est</li><li>Bade-Wurtemberg</li><li>Californie</li><li>District de Karlsruhe</li><li>District de Tübingen</li><li>Finlande occidentale</li><li>Floride</li><li>Grand Londres</li><li>Grand Manchester</li><li>Maryland</li><li>Massachusetts</li><li>Minnesota</li><li>Missouri (État)</li><li>Oxfordshire</li><li>Québec</li><li>Sofia-ville (oblast)</li><li>Svealand</li><li>Utah</li><li>Victoria (État)</li><li>Washington (État)</li><li>Île-de-France</li></region><settlement><li>Cambridge</li><li>Heidelberg</li><li>Londres</li><li>Manchester</li><li>Melbourne</li><li>Montréal</li><li>Oxford</li><li>Sofia</li><li>Stockholm</li><li>Turku</li><li>Ulm</li><li>Évry (Essonne)</li></settlement><orgName><li>University College de Londres</li><li>Université d'Oxford</li><li>Université de Cambridge</li><li>Université de Manchester</li><li>Université de Melbourne</li><li>Université de Turku</li></orgName></list><tree><noCountry><name sortKey="Kote Jarai, Zsofia" sort="Kote Jarai, Zsofia" uniqKey="Kote Jarai Z" first="Zsofia" last="Kote-Jarai">Zsofia Kote-Jarai</name><name sortKey="Nordestgaard, B Rge G" sort="Nordestgaard, B Rge G" uniqKey="Nordestgaard B" first="B Rge G." last="Nordestgaard">B Rge G. Nordestgaard</name><name sortKey="Pandha, Hardev" sort="Pandha, Hardev" uniqKey="Pandha H" first="Hardev" last="Pandha">Hardev Pandha</name></noCountry><country name="Royaume-Uni"><noRegion><name sortKey="Bonilla, Carolina" sort="Bonilla, Carolina" uniqKey="Bonilla C" first="Carolina" last="Bonilla">Carolina Bonilla</name></noRegion><name sortKey="Al Olama, Ali Amin" sort="Al Olama, Ali Amin" uniqKey="Al Olama A" first="Ali Amin" last="Al Olama">Ali Amin Al Olama</name><name sortKey="Benlloch, Sara" sort="Benlloch, Sara" uniqKey="Benlloch S" first="Sara" last="Benlloch">Sara Benlloch</name><name sortKey="Bonilla, Carolina" sort="Bonilla, Carolina" uniqKey="Bonilla C" first="Carolina" last="Bonilla">Carolina Bonilla</name><name sortKey="Davey Smith, George" sort="Davey Smith, George" uniqKey="Davey Smith G" first="George" last="Davey Smith">George Davey Smith</name><name sortKey="Davey Smith, George" sort="Davey Smith, George" uniqKey="Davey Smith G" first="George" last="Davey Smith">George Davey Smith</name><name sortKey="Donovan, Jenny L" sort="Donovan, Jenny L" uniqKey="Donovan J" first="Jenny L." last="Donovan">Jenny L. Donovan</name><name sortKey="Easton, Doug" sort="Easton, Doug" uniqKey="Easton D" first="Doug" last="Easton">Doug Easton</name><name sortKey="Eeles, Rosalind" sort="Eeles, Rosalind" uniqKey="Eeles R" first="Rosalind" last="Eeles">Rosalind Eeles</name><name sortKey="Hamdy, Freddie C" sort="Hamdy, Freddie C" uniqKey="Hamdy F" first="Freddie C." last="Hamdy">Freddie C. Hamdy</name><name sortKey="Khaw, Kay Tee" sort="Khaw, Kay Tee" uniqKey="Khaw K" first="Kay-Tee" last="Khaw">Kay-Tee Khaw</name><name sortKey="Lewis, Sarah J" sort="Lewis, Sarah J" uniqKey="Lewis S" first="Sarah J." last="Lewis">Sarah J. Lewis</name><name sortKey="Lewis, Sarah J" sort="Lewis, Sarah J" uniqKey="Lewis S" first="Sarah J." last="Lewis">Sarah J. Lewis</name><name sortKey="Martin, Richard M" sort="Martin, Richard M" uniqKey="Martin R" first="Richard M." last="Martin">Richard M. Martin</name><name sortKey="Martin, Richard M" sort="Martin, Richard M" uniqKey="Martin R" first="Richard M." last="Martin">Richard M. Martin</name><name sortKey="Martin, Richard M" sort="Martin, Richard M" uniqKey="Martin R" first="Richard M." last="Martin">Richard M. Martin</name><name sortKey="Muir, Kenneth" sort="Muir, Kenneth" uniqKey="Muir K" first="Kenneth" last="Muir">Kenneth Muir</name><name sortKey="Muir, Kenneth" sort="Muir, Kenneth" uniqKey="Muir K" first="Kenneth" last="Muir">Kenneth Muir</name><name sortKey="Neal, David E" sort="Neal, David E" uniqKey="Neal D" first="David E." last="Neal">David E. Neal</name><name sortKey="Neal, David E" sort="Neal, David E" uniqKey="Neal D" first="David E." last="Neal">David E. Neal</name><name sortKey="Pashayan, Nora" sort="Pashayan, Nora" uniqKey="Pashayan N" first="Nora" last="Pashayan">Nora Pashayan</name><name sortKey="Pashayan, Nora" sort="Pashayan, Nora" uniqKey="Pashayan N" first="Nora" last="Pashayan">Nora Pashayan</name><name sortKey="Travis, Ruth C" sort="Travis, Ruth C" uniqKey="Travis R" first="Ruth C." last="Travis">Ruth C. Travis</name></country><country name="Australie"><region name="Victoria (État)"><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G." last="Giles">Graham G. Giles</name></region><name sortKey="Batra, Jyotsna" sort="Batra, Jyotsna" uniqKey="Batra J" first="Jyotsna" last="Batra">Jyotsna Batra</name></country><country name="Suède"><region name="Svealand"><name sortKey="Wiklund, Fredrik" sort="Wiklund, Fredrik" uniqKey="Wiklund F" first="Fredrik" last="Wiklund">Fredrik Wiklund</name></region><name sortKey="Gronberg, Henrik" sort="Gronberg, Henrik" uniqKey="Gronberg H" first="Henrik" last="Gronberg">Henrik Gronberg</name></country><country name="États-Unis"><region name="Californie"><name sortKey="Haiman, Christopher A" sort="Haiman, Christopher A" uniqKey="Haiman C" first="Christopher A." last="Haiman">Christopher A. Haiman</name></region><name sortKey="Blot, William J" sort="Blot, William J" uniqKey="Blot W" first="William J." last="Blot">William J. Blot</name><name sortKey="Cannon Albright, Lisa" sort="Cannon Albright, Lisa" uniqKey="Cannon Albright L" first="Lisa" last="Cannon-Albright">Lisa Cannon-Albright</name><name sortKey="Kibel, Adam S" sort="Kibel, Adam S" uniqKey="Kibel A" first="Adam S." last="Kibel">Adam S. Kibel</name><name sortKey="Kibel, Adam S" sort="Kibel, Adam S" uniqKey="Kibel A" first="Adam S." last="Kibel">Adam S. Kibel</name><name sortKey="Park, Jong" sort="Park, Jong" uniqKey="Park J" first="Jong" last="Park">Jong Park</name><name sortKey="Stanford, Janet L" sort="Stanford, Janet L" uniqKey="Stanford J" first="Janet L." last="Stanford">Janet L. Stanford</name><name sortKey="Stanford, Janet L" sort="Stanford, Janet L" uniqKey="Stanford J" first="Janet L." last="Stanford">Janet L. Stanford</name><name sortKey="Thibodeau, Stephen" sort="Thibodeau, Stephen" uniqKey="Thibodeau S" first="Stephen" last="Thibodeau">Stephen Thibodeau</name></country><country name="Finlande"><region name="Finlande occidentale"><name sortKey="Schleutker, Johanna" sort="Schleutker, Johanna" uniqKey="Schleutker J" first="Johanna" last="Schleutker">Johanna Schleutker</name></region><name sortKey="Schleutker, Johanna" sort="Schleutker, Johanna" uniqKey="Schleutker J" first="Johanna" last="Schleutker">Johanna Schleutker</name></country><country name="Allemagne"><region name="Bade-Wurtemberg"><name sortKey="Maier, Christiane" sort="Maier, Christiane" uniqKey="Maier C" first="Christiane" last="Maier">Christiane Maier</name></region><name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name><name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name><name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name><name sortKey="Maier, Christiane" sort="Maier, Christiane" uniqKey="Maier C" first="Christiane" last="Maier">Christiane Maier</name></country><country name="Pologne"><noRegion><name sortKey="Cybulski, Cezary" sort="Cybulski, Cezary" uniqKey="Cybulski C" first="Cezary" last="Cybulski">Cezary Cybulski</name></noRegion></country><country name="Bulgarie"><region name="Sofia-ville (oblast)"><name sortKey="Kaneva, Radka" sort="Kaneva, Radka" uniqKey="Kaneva R" first="Radka" last="Kaneva">Radka Kaneva</name></region></country><country name="Portugal"><noRegion><name sortKey="Teixeira, Manuel R" sort="Teixeira, Manuel R" uniqKey="Teixeira M" first="Manuel R." last="Teixeira">Manuel R. Teixeira</name></noRegion><name sortKey="Teixeira, Manuel R" sort="Teixeira, Manuel R" uniqKey="Teixeira M" first="Manuel R." last="Teixeira">Manuel R. Teixeira</name></country><country name="France"><region name="Île-de-France"><name sortKey="Lathrop, Mark" sort="Lathrop, Mark" uniqKey="Lathrop M" first="Mark" last="Lathrop">Mark Lathrop</name></region></country><country name="Canada"><region name="Québec"><name sortKey="Lathrop, Mark" sort="Lathrop, Mark" uniqKey="Lathrop M" first="Mark" last="Lathrop">Mark Lathrop</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001876 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001876 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Asie
|area= AustralieFrV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:4820939
|texte= Pubertal development and prostate cancer risk: Mendelian randomization study in a population-based cohort
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:27044414" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a AustralieFrV1
| This area was generated with Dilib version V0.6.33. |  |